Lose weight. Keep it off.
Do you ever feel like you’re trapped in an endless cycle of trying to lose weight? If so, we can help. CONTRAVE® is an FDA-approved weight-loss medication that may help adults who are overweight or struggle with obesity lose weight and keep it off.
Lose 2-4x more weight on average than with diet and exercise alone.
Across three 56-week studies, patients taking CONTRAVE lost approximately 2-4x more weight on average than with diet and exercise alone. 46% of patients on CONTRAVE lost 5% or more body weight (vs 23% of patients on placebo).
Reduce hunger and control cravings to lose weight and keep it off.
CONTRAVE is believed to work on two important areas of the brain—your hunger center and your reward system—to reduce hunger and help control cravings.
WHAT IS CONTRAVE?
CONTRAVE® (naltrexone HCI/bupropion HCl) is a prescription weight-loss medicine that may help adults with obesity (BMI greater than or equal to 30 kg/m2), or who are overweight (BMI greater than or equal to 27 kg/m2) with at least one weight-related medical condition, lose weight and keep the weight off. CONTRAVE should be used along with diet and exercise.
WHAT ARE THE MAIN INGREDIENTS OF CONTRAVE?
CONTRAVE contains two well-known FDA-approved drugs, naltrexone and bupropion that, individually, have been on the market for over 30 years. Naltrexone is an anti-addiction medication approved to treat alcohol and opioid dependence. Bupropion is an antidepressant approved to treat depression and seasonal affective disorder and is an aid to smoking cessation treatment. (These individual drugs are not approved for weight loss and CONTRAVE is not indicated for the treatment of depression, smoking cessation, or alcohol or opioid dependence.)
HOW DOES CONTRAVE WORK?
The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood. CONTRAVE is believed to work on two areas of the brain—the hypothalamus (your hunger center) to help reduce hunger and the mesolimbic reward system to help control cravings—that can get in the way of weight loss. Across three one-year studies, nearly half of patients taking CONTRAVE along with diet and exercise lost 5% or more of their body weight versus 23% of patients with diet and exercise alone (placebo).
WHO SHOULD TAKE CONTRAVE?
CONTRAVE is approved for use in adults with a body mass index (BMI) of 30 or greater (obese) or 27 or greater (overweight) who have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. It is to be used along with a reduced-calorie diet and increased physical activity.
CONTRAVE is not for everyone. Do not take CONTRAVE if you:
Have a seizure disorder
Are pregnant or trying to get pregnant
Have an eating disorder such as anorexia or bulimia
Are under the age of 18
Have uncontrolled hypertension
Use other medicines that contain bupropion such as Wellbutrin and Aplenzin
Are dependent on opioid medicines or use medicines to help stop taking opioids, such as methadone or buprenorphine or are in opiate withdrawal
Drink a lot of alcohol and abruptly stop drinking
Use medicines called sedatives like benzodiazepines, or anti-seizure medicines, and you stop using them suddenly
Are allergic to any of the ingredients in CONTRAVE, such as naltrexone HCI and bupropion HCI
Are taking medicines called monoamine oxidase inhibitors (MAOIs)
See the Medication Guide to learn more.
HOW MUCH DOES CONTRAVE COST?
CONTRAVE is only $99/month!* If you are not prescribed the medication during your Dr. consult, you will not be charged for the medication ($45 Dr. Consult fee still applies).
Your credit card will be charged for the medication once the product is shipped. Cancel monthly subscription anytime.
*$45 physician fee applies for each Dr. consult.
WHAT SHOULD I KNOW WHEN STARTING CONTRAVE?
HOW TO TAKE CONTRAVE
CONTRAVE should be taken by mouth in the morning and in the evening and should not be taken with high-fat meals.
CONTRAVE dosing should be increased slowly according to the following schedule:
Standard Dosage for Patients Taking Contrave
Tablets not shown to size.
It’s important to take CONTRAVE exactly as your doctor prescribes it. Keep in mind that some people, like those with renal or hepatic impairment, or those taking certain other medications, may need to follow a different dosing schedule. A total daily dosage of four CONTRAVE tablets (i.e., two tablets taken twice per day) should be reached at the start of week four.
To learn more about dosing, see the Medication Guide.
COMMON SIDE EFFECTS & TIPS FOR MANAGING THEM
The most common side effects reported with CONTRAVE include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. For most people, these symptoms went away within the first four weeks of taking CONTRAVE. If symptoms do not improve, please consult with your healthcare provider.
In general, it is recommended you drink plenty of water when taking CONTRAVE. If you experience nausea, you may also want to eat a small amount of dry toast with CONTRAVE. If symptoms do not improve, please consult with your doctor who may also recommend an over-the-counter anti-nausea medication for you.
WHAT ARE THE SERIOUS SIDE EFFECTS OF CONTRAVE?
If you experience any of the following, stop taking CONTRAVE and tell your healthcare provider right away:
Suicidal thoughts or actions
Increases in blood pressure or heart rate
Liver damage or hepatitis (symptoms include stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness)
Visual problems (symptoms include eye pain, changes in vision, swelling or redness in or around the eye)
Low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas)
Severe allergic reaction (signs and symptoms include rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing)
See the Full Prescribing Information or the Medication Guide to learn more about the possible side effects of CONTRAVE.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.
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In case of medical emergency, please contact your local Physician or hospital for immediate care. Do not rely on your online Physician for emergency medical care.